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Representative Publications
Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo
5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity
Gambogic acid and juglone inhibit RNase P through distinct mechanisms
Pseudouridine synthase 7 is an opportunistic enzyme that binds and modifies substrates with diverse sequences and structures
Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P
An itaconyl-CoA-derived biradical on methylmalonyl-CoA mutase inhibits propionate metabolism
Interplay between substrate recognition, 5' end tRNA processing and methylation activity of human mitochondrial RNase P
Thermus thermophilus cobalamin-dependent methionine synthase folate-binding module displays a distinct variance of the classical TIM barrel; a TIM barrel with a "twist"
Antivitamin B12 inhibition of B12-Dealkylation by human B12 processing enzyme CblC - Crystal structure of abortive ternary complex with co-substrate glutathione
Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P
Coordination chemistry controls the thiol oxidase activity of the B12-trafficking protein CblC
Loss of the mitochondrial protein-only ribonuclease P complex causes aberrant tRNA processing and lethality in Drosophila
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